DNA supercoiling during transcription
نویسندگان
چکیده
منابع مشابه
Supercoiling of the DNA template during transcription.
Transcription of a right-handed double-helical DNA requires a relative rotation of the RNA polymerase and its nascent RNA around the DNA. We describe conditions under which the resistance to the rotational motion of the transcription ensemble around the DNA can be large. In such cases, the advancing polymerase generates positive supercoils in the DNA template ahead of it and negative supercoils...
متن کاملInterplay between DNA supercoiling and transcription elongation.
Transcription-coupled DNA supercoiling has been shown to be an important regulator of transcription that is broadly present in the cell. Here we review experimental work which shows that RNA polymerase is a powerful torsional motor that can alter DNA topology and structure, and DNA supercoiling in turn directly affects transcription elongation.
متن کاملThe benefit of DNA supercoiling during replication.
DNA topology changes dynamically during DNA replication. Supercoiling, precatenation, catenation and knotting interplay throughout the process that is finely regulated by DNA topoisomerases. In the present article, we provide an overview of theoretical and experimental approaches to understand the interplay between various manifestations of topological constraints acting on replicating DNA mole...
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Regulation of transcription in eukaryotes is considered in the light of recent findings demonstrating the presence of negative and positive superhelical tension in chromatin. This tension induces conformational transitions in DNA duplex. Particularly, the transition into A-form renders DNA accessible and waylaying for initiation of transcription producing RNA molecules long known to belong to t...
متن کاملTranscription-driven DNA supercoiling and gene expression control.
DNA supercoiling plays important roles in gene expression regulation, although, the underlying mechanisms whereby DNA supercoiling modulates gene expression remain elusive. The fact that the transcription process itself generates DNA supercoiling has further complicated the issue. Transcription-driven DNA supercoiling is local and transient. Such a DNA supercoiling effect is likely to play impo...
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ژورنال
عنوان ژورنال: Biophysical Reviews
سال: 2016
ISSN: 1867-2450,1867-2469
DOI: 10.1007/s12551-016-0215-9